Planning for Complementarity: An Examination of the Roll and Opportunities of First-Tier and Second-Tier Cities Along the High-Speed Rail Network in California, Research Report 11-17

The coming of California High-Speed Rail (HSR) offers opportunities for positive urban transformations in both first-tier and second-tier cities. The research in this report explores the different but complementary roles that first-tier and second-tier cities along the HSR network can play in making California more sustainable and less dependent on fossil fuels while reducing mobile sources of greenhouse gas emissions and congestion at airports and on the state’s roadways. Drawing from case studies of cities in Northern and Southern California, the study develops recommendations for the planning, design, and programming of areas around California stations for the formation of transit-supportive density nodes

Editorial [1/2]

“The future is already here. It is just not very evenly distributed.” William Gibson This issue of Ardeth began in the time of travel, public gathering, and a worsening housing crisis when we asked the authors to think about their topics through the lens of contingency. This issue is completed from within contingent times, when nothing seems certain and contingency is less a lens than the air we breathe. It spans the current coronavirus epidemic, the before and the present of Covid-19, which ..

Editorial [1/2]

“Il futuro è già qui. Solo che non è distribuito in modo molto equo.” William Gibson Questo numero di Ardeth è cominciato in un tempo di viaggi, incontri pubblici, e nel mezzo di una crescente crisi residenziale, allorché abbiamo chiesto agli autori di riflettere sui loro temi di ricerca attraverso la lente della contingenza. La produzione del numero si chiude in tempi di contingenza, quando niente può offrire certezza e la contingenza, piuttosto che una lente, è nell’aria che respiriamo quot..

Lessons About Projecting the Metropolis

The city is an object of study, a site of practice, a material artifact of power, and the locus of the imaginary. It is a cultural formation, warranting attention from anthropologists along with many others. It eludes disciplining. It resists singular descriptions. It condemns us to work together. This essay considers the particular ways in which the city can serve as an object of scholarly investigation, dealing with research experiences carried out at UCLA and setting new methodological proposals in the field of spatial ethnography

Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains

Genome3D, available at http://www.genome3d.eu, is a new collaborative project that integrates UK-based structural resources to provide a unique perspective on sequence-structure-function relationships. Leading structure prediction resources (DomSerf, FUGUE, Gene3D, pDomTHREADER, Phyre and SUPERFAMILY) provide annotations for UniProt sequences to indicate the locations of structural domains (structural annotations) and their 3D structures (structural models). Structural annotations and 3D model predictions are currently available for three model genomes (Homo sapiens, E. coli and baker's yeast), and the project will extend to other genomes in the near future. As these resources exploit different strategies for predicting structures, the main aim of Genome3D is to enable comparisons between all the resources so that biologists can see where predictions agree and are therefore more trusted. Furthermore, as these methods differ in whether they build their predictions using CATH or SCOP, Genome3D also contains the first official mapping between these two databases. This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs)

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead